Relationship between diuretic and antihypertensive effects of chlorothiazide and mercurial diuretics.

Mechanism of the antihypertensive effects of diuretics. Possible role of salt in hypertension.

The mechanism of the antihypertensive effect of chlorothiazide does not difler from that of such potent salt-depleting therapeutic agents as the mercurial diuretics and tlw rice diet. The extracellular fluid and plasma volumes are reduced and, as 44 result, right hecrrt filling pressure, cardiac output, and blood pressure (if abnormally elevated by some pressor stimu1u.y) fall. Becal4se of the ...

For the Preparation of Intravenous Solutions

Chlorothiazide sodium for injection, USP is a sterile lyophilized white powder and is supplied in a vial containing: Chlorothiazide sodium equivalent to chlorothiazide 500 mg, and the inactive ingredient mannitol 250 mg with sodium hydroxide to adjust pH. Chlorothiazide is a diuretic and antihypertensive. It is 6-chloro-2H-1,2,4-benzothiadiazine-7sulfonamide 1,1-dioxide, and its structural form...

Effects of reduced glomerular filtration rate on responsiveness to chlorothiazide and mercurial diuretics.

Treatment of essential hypertension with chlorothiazide (diuril); its use alone and combined with other antihypertensive agents.

Chlorothiazide (Diuril) was synthesized by Novello and Sprague, who also reported on its diuretic properties.’ Pharmacological studies in animals revealed that the orally administered drug produced a marked increase in the urinary excretion of sodium, potassium, and chloride.” No evidence of tolerance developed on continued administration. Ford and Moyer and their co-workers confirmed in man th...

Potassium-sparing effects of triamterene in the treatment of hypertension.

T RIAMTERENE (2,4,7-triamino-6-phenylpteridine) is the first of a relatively new class of diuretics to become available for clinical investigation and therapeutic use. It has been demonstrated to be an antagonist of mineralocorticoids in addition to having a direct diuretic effect in adrenalectomized animals and humans.1-7 Administration of triamterene increases the urinary excretion of sodium,...